| Date | Home team | Result | Away team | Comp | Blackburn scorers / Venue |
| 30/07/21 | Blackburn United | 2-2 | Hill of Beath Hawthorn | League | Sweeney, Donald |
| 06/08/21 | Blackburn United | 0-4 | Lothian Thistle HV | L | – |
| 13/08/21 | Blackburn United | 1-3 | Fauldhouse United | L | Osborne |
| 20/08/21 | Blackburn United | 4-1 | Craigroyston | L | McKeon 2, Duncan, Thomas |
| 27/08/21 | Oakley United | 4-1 | Blackburn United | L | Brogan |
| 03/09/21 | Blackburn United | 1-2 | Dunipace | L | Ferris |
| 10/09/21 | Glenrothes | 0-5 | Blackburn United | ELC1 | Stewart 3, McKeon, Ferris |
| 17/09/21 | Jeanfield Swifts | 1-6 | Blackburn United | L | Stewart 3, Spaloney, Brogan, Mencis |
| 24/09/21 | Blackburn United | 1-4 | Leith Athletic | L | Stewart |
| 01/10/21 | Livingston United | 1-4 | Blackburn United | L | Stewart 3, Osborne |
| 08/10/21 | Blackburn United | 2-1 | Tynecastle | L | Stewart, Thomas |
| 15/10/21 | Inverkeithing Hillfield Swifts | 2-1 | Blackburn United | L | Osborne |
| 22/10/21 | Blackburn United | 2-3 | Newtongrange Star | L | Osborne, Thomson |
| 29/10/21 | Oakley United | 2-3 | Blackburn United | EKC1 | Stewart 2, Osborne |
| 05/11/21 | Dalkeith Thistle | 1-1 | Blackburn United | L | Stewart |
| 12/11/21 | Hill of Beath Hawthorn | 4-3 | Blackburn United | L | Thomas 2, Spaloney |
| 19/11/21 | Lothian Thistle HV | 6-0 | Blackburn United | L | – |
| 03/12/21 | Craigroyston | 2-1 | Blackburn United | L | Stewart |
| 10/12/21 | Blackburn United | 1-3 | Oakley United | L | Ferris |
| 17/12/21 | Penicuik Athletic | W/O | Blackburn United | ELC2 | – |
| 14/01/22 | Dunipace | 1-2 | Blackburn United | L | Ferris 2 |
| 21/01/22 | Blackburn United | 4-2 | Spartans | EKC2 | Ferris 3, Wallace |
| 28/01/22 | Leith Athletic | 4-0 | Blackburn United | L | – |
| 04/02/22 | Blackburn United | 9-2 | Livingston United | L | Ferris 6, Stewart, Garrad |
| 11/02/22 | Tynecastle | 1-0 | Blackburn United | L | – |
| 18/02/22 | Blackburn United | 5-1 | Inverkeithing HS | L | Stewart 2, Thomas, Osborne, Seagust |
| 25/02/22 | Bonnyrigg Rose | 2-2 (5-3p) | Blackburn United | ELC3 | Thomas, Ferris |
| 04/03/22 | East Fife | 1-1 (5-6p) | Blackburn United | EKC3 | Ferris |
| 11/03/22 | Newtongrange Star | 6-0 | Blackburn United | L | – |
| 18/03/22 | Blackburn United | 4-1 | Dalkeith Thistle | L | Landels, Ferris, Jollie, Stewart |
| 25/03/22 | Blackburn United | 4-0 | Penicuik Athletic | CC2 | Ferris 2, McKeon, Stewart |
| 01/04/22 | Fauldhouse United | 2-1 | Blackburn United | L | Osborne |
| 08/04/22 | Blackburn United | 0-3 | Broomhill | CC3 | – |
| 22/04/22 | Blackburn United | 2-0 | Jeanfield Swifts | L | Thom, Stewart |
| 29/04/22 | Blackburn United | Cumbernauld Colts | EKC4 | New Murrayfield Park, 20.00 |
